Category: Completed Projects
-
Evaluation of new C-TAF1 and N-TAF1 antisera by immunohistology in normal human brain sections
-
Leveraging novel AAV capsids and CRISPR/Cas9 gene editing as a gene therapeutic approach to target the XDP-SVA
-
SVA-mediated chromatin re-organisation in XDP
-
Characterization of SVA retrotransposon dynamics in iPS-derived organoid models and postmortem tissue of X-Linked Dystonia-Parkinsonism
-
Towards targeted neutralization of the disease causing SVA in XDP brain organoids
-
The role of Olig2 transcription factor in striosome development, function, and X-linked dystonia parkinsonism
-
Cell-based screening of chemical compounds countering XDP-SVA mediated disruption of TAF1 mRNA biosynthesis
-
Somatic repeat instability as a modifier of XDP pathogenesis
-
Identify disease targets and perturbagens that modulate XDP-disease phenotypes with robotic microscopy, deep learning and OMICS in human in vitro XDP cell models
-
Epigenetic regulation of the XDP-SVA and its link to XDP pathology